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Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery
anti-inflammatory
Product Name Thalidomide-O-C3-acid Synonyms Thalidomide-4'-O-C3-acid CAS Number 2169266-64-0 Related CAS Molecular Formula C17H16N2O7 Molecular Weight 360
Product Name BG-Nor Synonyms NorBG CAS Number Related CAS Molecular Formula C22H24N6O3 Molecular Weight 420
dCeMM2 induces ubiquitination and degradation of cyclin K by prompting an interaction of CDK12-cyclin K with a CRL4B ligase complex
Fmoc-Val-Ala-PAB(m-PEG8) Size:50mg Molecular Glues for Targeted ProteinSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate solubilizing moietiessuch as PEG, amine containing groups, or polysarcosine (PSAR), to enhance aqueous solubility. Solubility and physicochemical properties can be finely tuned
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