Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE amine-acid 525 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC(=CC=C2C([O-])=O)C(=O)NCC#C)=[N+](C)C)=C1 Purity (HPLC):

525 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC(=CC=C2C([O-])=O)C(=O)NCC#C)=[N+](C)C)=C1 Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Coumarin (353Ex/434Em) has moderate to high quantum yields and extinction coefficients

Contains an E3 ligase ligand substituted with piperazine

Product Name Lenalidomide-PEG1-C2-acid Synonyms Lenalidomide-4'-PEG1-C2-acid CAS Number 2225148-47-8 Related CAS Molecular Formula C18H21N3O6 Molecular Weight 375

Product Name Thalidomide-O-acetamido-C6-amine HCl Synonyms Thalidomide-4'-O-acetamido-C6-amine HCl CAS Number 2376990-31-5 Related CAS 1950635-13-8 (free base)

Propargyl-Gly(m-PEG4)-Val-Cit-PAB(m-PEG8)-MMAE amine-acid 525 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC(=CC=C2C([O-])=O)C(=O)NCC#C)=[N+](C)C)=C1 Purity (HPLC):SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Propargyl Gly(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The propargyl functional group is widely employed in click chemistry to undergo selective cycloaddition with azides. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The