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HQ461 is a molecular glue that promotes CDK12-DDB1 interaction to trigger cyclin K degradation
15 SMILES Cl
48 SMILES Cl
Its exceptional stability and versatility make it a cornerstone in applications like medical imaging
025 Purity (HPLC) >= 95% Physical Appearance White Solid Optical Properties n/a Solubility DMSO
Azide-Lys(m-PEG4)-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan cr6g HQ461 is a molecular glueSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. In this product, a Azide Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further
