Mal-Propionyl-PEG2-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan trametiglue Small-molecule-induced polymerization triggers degradation of

Small-molecule-induced polymerization triggers degradation of BCL6

Cy3 carboxylic acid

CA-Lissamine Rhodamine B is a HaloTag Ligand containg Lissamine Rhodamine B dye and it forms a covalent bond with the HaloTag protein

DBCO-Biotin is a biotinylation reagent

798 SMILES: CC(C)(C)C(=O)OC1=CC2=C(C=C1)C1(OC(=O)C3=CC(=CC=C13)C(=O)NCCOCCOCCOCCN=[N]#N)C1=CC=C(OC(=O)C(C)(C)C)C=C1O2

Mal-Propionyl-PEG2-Gly-Gly-Phe-Gly-PAB(m-PEG4)-Exatecan trametiglue Small-molecule-induced polymerization triggers degradation ofSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. The conventional maleimidocaproyl (MC) unit is replaced by Mal Propionyl PEG2 moiety to enhance aqueous solubility. The Mal Propionyl group may also improve retro Michael addition stability during antibody conjugation. m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent