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85 SMILES Cl
By combining P1 and P18
308 SMILES O=C1N(C2CCC(=O)NC2=O)C(=O)C2=C(OCCC#C)C=CC=C12 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
HaXS8 bridges HaloTag and SNAP-tag fusion proteins by reacting covalently with their respective active sites: the chloroalkane binds irreversibly to HaloTag’s modified dehalogenase pocket
and a C-terminal 7-Amino-4-methylcoumarin (AMC) moiety
Mal-Propionyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-MMAE gly 85 SMILES ClSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate
