Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE m-peg8-pab A Cereblon Modulator (CC-220) with

A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos

Product Name Phthalimidinoglutarimide-propargyl-amine HCl Synonyms Phthalimidinoglutarimide-4'-propargyl-amine HCl CAS Number 2138440-38-5 Related CAS Molecular Formula C16H16ClN3O3 Molecular Weight 333

506 SMILES OC(=O)CCOCCOCCOCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name: 5(6)-FAM PEG3 alkyne Synonyms: 5-(and 6)-Carboxyfluorescein-PEG3-alkyne CAS Number: N/A Molecular Formula: C30H27NO9 Molecular Weight: 545

891 SMILES OC(=O)CN1CCN(CC(O)=O)CCN(CC(=O)NCCOCCOCCOCCOCCOCCNC(=O)CCN2C(=O)C=CC2=O)CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Azide-Dap(m-PEG4)-Val-Cit-PAB(m-PEG4)-MMAE m-peg8-pab A Cereblon Modulator (CC-220) withSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a Azide Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The azide functional group is widely utilized in bioconjugation via click chemistry to enable efficient and selective attachment of biomolecules. Additionally, m PEG4 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase