DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP Size:100mg [O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCCCN=[N]#N Purity (HPLC): ≥ 95%

[O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCCCN=[N]#N Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

Product Name Pomalidomide-5'-PEG6-OH Synonyms CAS Number 2641838-86-8 Related CAS Molecular Formula C25H35N3O10 Molecular Weight 537

It is based on a proximity-induced covalent Michael addition between an engineered cysteine (Cys) residue in Escherichia coli dihydrofolate reductase (eDHFR) and optimized trimethoprim (TMP)-acrylamide conjugates with minimal linker lengths

87 SMILES: NCCCCCNS(=O)(=O)C1=CC=C(C(=C1)C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)S([O-])(=O)=O

507 SMILES [H][C@@]1(CCC(=O)NC1=O)N1CC2=C(C=CC=C2OCC2=CC=C(CN3CCOCC3)C=C2)C1=O Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

DBCO-Lys(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP Size:100mg [O-]C(=O)C1=CC(=CC=C1C1=C2C=C3CCC[N+]4=C3C(CCC4)=C2OC2=C3CCCN4CCCC(C=C12)=C34)C(=O)NCCCN=[N]#N Purity (HPLC): ≥ 95%SOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Lys(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further