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O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC(=CC=C12)N1CCN(CCN2CCNCC2)CC1 Purity (HPLC) 95% Shipping Conditions Room Temperature Storage Conditions Refrigerated Regulatory Statemen: For Research Use Only
Product Name NRX-103095 Synonyms CAS Number 2763260-38-2 Related CAS Molecular Formula C22H16Cl2F3N3O3S Molecular Weight 530
1 Purity (HPLC) >= 95% Physical Appearance Yellow Solid Optical Properties Abs/Em Maxima: 496/516 nm Solubility DMSO
89 SMILES ClCCOCCOCCOCC(=O)NC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
NCCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only
Azide-Propionyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-Exatecan macrophage O=C1N(C2CCC(=O)NC2=O)C(=O)C2=CC(=CC=C12)N1CCN(CCN2CCNCC2)CC1 Purity (HPLC) 95% ShippingSOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU
