SHP099 deuterium-labeled-carboxylic acid 4-(4-piperidinyl)-

4-(4-piperidinyl)-

194 SMILES [2H]C([2H])([2H])OC1=CC=C(C=C1)C(=O)OC Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

23 SMILES CC1=CC=C(C=C1)S(=O)(=O)N\N=C\C1=C(O)C=CC(Br)=C1 Purity (HPLC) >= 95% Physical Appearance White solid Solubility DMSO

36 SMILES CC(C)(C)OC(=O)NCCN1CCN(CC(O)=O)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name DOTA-tris(t-Bu)ester-PEG5-C2-propanamido-maleimide Synonyms CAS Number n/a Related CAS Molecular Formula C47H83N7O15 Molecular Weight 986

SHP099 deuterium-labeled-carboxylic acid 4-(4-piperidinyl)-SHP099 is a highly potent (IC50 = 0. 071uM),selective and orally bioavailable small molecule SHP2 inhibitor. The inhibiting SHP2 activity of SHP099 is through an allosteric mechanism. SHP099 suppresses RASERK signalling to inhibit the proliferation of receptor tyrosine kinase driven human cancer cells in vitro and is efficacious in mouse tumour xenograft models. Product Name SHP099 Synonyms CAS Number 1801747 42 1 Related CAS Molecular Formula