DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP Size:50mg HaloPROTACS: Use of Small Molecule

HaloPROTACS: Use of Small Molecule PROTACs to Induce Degradation of HaloTag Fusion Proteins

while the BG moiety forms a stable thioether bond with SNAP-tag’s engineered alkyltransferase cysteine

472 Purity (HPLC) >= 95% Solubility DMSO

Product Name Thalidomide-5'-O-C3-OH Synonyms CAS Number 2476318-89-3 Related CAS Molecular Formula C16H16N2O6 Molecular Weight 332

495 SMILES: NCCCCC(NC(=O)C1=CC=C2C(=C1)C(=O)OC21C2=CC=C(O)C=C2OC2=C1C=CC(O)=C2)C(O)=O Purity (HPLC): ≥ 95% Shipping Conditions: room temperature Storage Conditions: Refrigerated Regulatory Statement: For Research Use Only

DBCO-Dap(m-PEG4)-Val-Cit-PAB(m-PEG8)-PNP Size:50mg HaloPROTACS: Use of Small MoleculeSOLU KNEX cleavable linker features a Val Cit dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further